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Mycobacterium tuberculosis Complex Detection and Rifampin Resistance by PCR
Ordering Recommendation
Panel includes PCR testing to detect M. tuberculosis complex isolates and determine possible resistance to rifampin treatment. Test may be ordered for client-processed specimens. Refer to specimen requirements.
New York DOH Approval Status
Specimen Required
Respiratory specimens, CSF, pleural fluid, or tissue.
Unprocessed Specimens: Transport 5-10 mL respiratory specimen, CSF or pleural fluid (Min: 1 mL) in a sterile container, or tissue large enough to be ground. Label as unprocessed.
Processed Specimens: Transport 2-5 mL digested/decontaminated respiratory specimen, CSF, pleural fluid, or tissue in a sterile container. (Min: 1 mL)
Place each specimen in an individually sealed bag.
Refrigerated.
Blood, paraffin blocks, stool, swabs, and urine.
Specimen source required. Processed Specimens: Identify method used for digestion and provide smear results.
Unprocessed: Ambient: 3 days; Refrigerated: 1 week; Frozen: 1 month
Processed: Ambient: Unacceptable; Refrigerated: 1 week; Frozen: 1 month
Methodology
Qualitative Polymerase Chain Reaction (PCR)
Performed
Sun-Sat
Reported
1-3 days
Reference Interval
Interpretive Data
Mycobacterial culture is a more sensitive method than molecular testing for the diagnosis of tuberculosis and is still considered the gold standard. When possible, a culture must be performed regardless of the molecular method test result.
Depends on Specimen/Source/Method
Note
Body fluids other than pleural fluid will be run with a disclaimer.
Specimen source required. To perform this test, it is essential to know whether or not the submitted specimen has been processed (digestion and decontamination procedure). If processed, smear results must be provided as a comment on the test order or requisition. Delayed turnaround time will occur if the required information is not provided.
After a positive result, repeat orders for Mycobacterium tuberculosis Complex Detection and Rifampin Resistance by PCR will continue to yield a positive result and repeat testing is not clinically indicated.
The Xpert MTB/RIF test performance has not been evaluated with samples from pediatric patients.
Hotline History
CPT Codes
87556; 87798
Components
| Component Test Code* | Component Chart Name | LOINC |
|---|---|---|
| 2010776 | MTBRIF Source | 31208-2 |
| 2010777 | Mycobacterium Tuberculosis by PCR | 38379-4 |
| 2010778 | MTB Rifampin by PCR | 89372-7 |
| 2010779 | MTB Cmplx Interpretation | 93479-4 |
Aliases
- MC MTD
- MC MTDCSF
- MTB PCR
- MTD PCR
